Interventional Oncology in the Future

Targeted CE per ARRT’s Discipline, Category, and Subcategory classification:
[Note: Discipline-specific Targeted CE credits may be less than the total Category A credits approved for this course.]

Vascular-Interventional Radiography: 0.75
Procedures: 0.75
Nonvascular Procedures: 0.75

Outline

1. Introduction
2. Precision Interventional Oncology in 2043
   1. Precision Oncology and Tumor Biomarkers
   2. Precision Interventional Oncology and Genetic Editing
3. Immunotherapy and Locoregional Interventions
   1. Combination Therapy
   2. Locoregional Immunotherapy Delivery
4. Advances in Imaging and Navigation
   1. Multimodality Imaging: An Integrated Interventional Oncology Suite
   2. Multimodality Imaging: Molecular and Functional Imaging
   3. Three-Dimensional Reconstruction, Image Fusion, and Electromagnetic Navigation
   4. Virtual and Augmented Reality for Interventional Oncology Training and Procedures
   5. AI and Deep Learning
5. Transarterial Therapies beyond HCC
   1. Liver-Directed Therapies for Primary and Metastatic Cancer
   2. Advances in Radioembolization
   3. Transarterial Therapies beyond the Liver
6. The Expanding Role of Ablation
   1. Ablation beyond the Liver
   2. Innovating Thermal Ablation
   3. Nonthermal ablation with Pulsed Electric Field
   4. Nonthermal Ablation with Histotripsy
7. Beyond Tumor-Directed Therapies
   1. Lymphatic Interventions
   2. Palliation of Neuropathic and Musculoskeletal Pain
   3. Biliary Interventions
   4. Vascular Interventions
8. Interventional Oncology Research and Training
9. Conclusion

Objectives

Upon completion of this course, students will:

1. identify parallels between the emergence of interventional oncology and the evolution of surgical oncology
2. discuss why interventional radiologists might frequently be the first cancer specialists to see a patient suspected of having cancer in the future
3. determine the applications of precision oncology
4. recognize the limitations of tissue biopsy for genetic sequencing
5. identify a major technical challenge in gene editing using the CRISPR-Cas9 system
6. describe the reasons for the limited efficacy of immune checkpoint inhibitors in some patients
7. explain how combination therapy with locoregional interventions and immunotherapy may overcome the limitations of immune checkpoint inhibitors
8. recognize potential advantages of percutaneous and transarterial delivery of immune agents compared to systemic administration
9. identify commonly combined imaging modalities in modern interventional oncology practices
10. recognize a primary challenge of ablation that imaging software aims to address
11. describe how PET/CT-guided ablation contributes to interventional oncology
12. describe how image fusion in interventional oncology benefits from integrating software and devices
13. explain the role of electromagnetic navigation systems in interventional oncology
14. define augmented reality in the context of medical imaging
15. identify the primary use of virtual reality in interventional oncology
16. recognize primary hindrances to the adoption of robotic devices in interventional oncology
17. define radiomics in the context of medical imaging
18. identify the benefits of transarterial therapy besides tumor treatment
19. recognize the cancers being investigated for ⁹⁰Y radioembolization
20. identify a true statement regarding interventional oncology therapies
21. describe the role of ablation in cancer treatment
22. describe the iterations of ablation devices that might address the challenges of thermal ablation near sensitive structures
23. describe irreversible electroporation as a nonthermal ablative modality
24. discuss cryoneurolysis as a method for treating neuropathic pain
25. identify significant obstacles in treating malignant biliary obstruction
26. identify an intervention for noncirrhotic portal hypertension in cancer patients
27. recognize cancers treated with chimeric antigen receptor (CAR) T-cell therapy
28. identify potential solutions to address the challenge of providing sufficient training volumes in interventional